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reported that rifampicin amplified the metabolism of R- and S-methadone while the CYP3A selective inhibitor troleandamycin did not have any effect to the enantiomers.Receive baseline ECG (Appraise QTc interval) ahead of therapy in patients with chance factors for QTc interval prolongation, a prior ECG with a QTc >450 msec, or maybe a history sugges